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Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs | Latest News

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and ... read more

Heat Shock Protein 60 and Immune Inflammatory Responses in Atherosclerosis

Under physiological conditions, vascular endothelial cells (ECs) do not express HSP60. However, when stressed by classical atherosclerosis risk factors, the simultaneous expression of adhesion molecules and HSP60 by ECs leads to a (cross)reaction against ... read more

Dynamics of heat shock protein 60 in endothelial cells exposed to cigarette smoke extract

Heat shock protein 60 ... of HSP60 mRNA after 24 h. CSE induces the upregulation of HSP60 mRNA, causes HSP60 release from mitochondria, and leads to HSP60 surface expression. A. Real-time PCR analysis of hspd1 mRNA in response to exposure of HUVECs ... read more

Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma

These results suggest that the high level of ROS is needed for tumorigenesis and progression in tumors with the low HSP60 expression and HSP60 is a ... Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive ... read more

Upregulation of DAPK contributes to homocysteine-induced endothelial apoptosis via the modulation of Bcl2/Bax and activation of caspase 3

Hyperhomocysteinemia is characterized by an abnormally high level of homocysteine (Hcy) in the blood and is associated with cardiovascular diseases such as atherosclerosis. Endothelial dysfunction may lead ... expression levels of apoptosis regulators ... read more

Photochemistry and Photobiology

In comparison with parental HT29 cells, mRNA expression was increased ... levels and inhibiting apoptosis (as reviewed in Ref. 32). In addition, we have reported previously that the PDT-resistant HT29-P14 cell variant expresses elevated Hsp27 compared ... read more

Loss of exocrine pancreatic stimulation during parenteral feeding suppresses digestive enzyme expression and induces Hsp70 expression

Secretagogues including CCK, acetylcholine, and bombesin stimulate acinar cell secretion via G protein-coupled receptors that activate PLC to ultimately increase ... Hsp70, Hsc70, Hsp60, Hsp27, IκB-α, lipase, and CRHSP24 expression were measured by ... read more

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

DOI: 10.1371/journal.pone.017938310.1371/journal.pone.0179383.g00110.1371/journal.pone.0179383.g00210.1371/journal.pone.0179383.g00310.1371/journal.pone.0179383.g00410.1371/journal.pone.0179383.s00110.1371/journal.pone.0179383.s00210.1371/journal.pone ... read more

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs.

Summary of "Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs." Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of ... read more
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