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Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs | Latest News

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and ... read more

Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma

These results suggest that the high level of ROS is needed for tumorigenesis and progression in tumors with the low HSP60 expression and HSP60 is a ... Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive ... read more

Dynamics of heat shock protein 60 in endothelial cells exposed to cigarette smoke extract

Heat shock protein 60 ... of HSP60 mRNA after 24 h. CSE induces the upregulation of HSP60 mRNA, causes HSP60 release from mitochondria, and leads to HSP60 surface expression. A. Real-time PCR analysis of hspd1 mRNA in response to exposure of HUVECs ... read more

Heat Shock Proteins in Pancreatic Diseases

Inhibition of HSP70 expression in pancreatic cancer cells leads to caspase-dependent ... in pancreatic diseases when we observed that HSP60 protects against pancreatitis in rats [10]. Water immersion stress induces a robust HSP60 synthesis response in ... read more

Upregulation of DAPK contributes to homocysteine-induced endothelial apoptosis via the modulation of Bcl2/Bax and activation of caspase 3

Hyperhomocysteinemia is characterized by an abnormally high level of homocysteine (Hcy) in the blood and is associated with cardiovascular diseases such as atherosclerosis. Endothelial dysfunction may lead ... expression levels of apoptosis regulators ... read more

Photochemistry and Photobiology

In comparison with parental HT29 cells, mRNA expression was increased ... levels and inhibiting apoptosis (as reviewed in Ref. 32). In addition, we have reported previously that the PDT-resistant HT29-P14 cell variant expresses elevated Hsp27 compared ... read more

Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression

In addition to decreased cardiac and hepatic function, there was an increase in cardiac HSP32 expression and a reduction in HSP60 expression after T-H. In the liver, HSP32 and HSP70 were increased after T-H. There was no change in heart HSP70 and liver ... read more

Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs

DOI: 10.1371/journal.pone.017938310.1371/journal.pone.0179383.g00110.1371/journal.pone.0179383.g00210.1371/journal.pone.0179383.g00310.1371/journal.pone.0179383.g00410.1371/journal.pone.0179383.s00110.1371/journal.pone.0179383.s00210.1371/journal.pone ... read more
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