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The role of miR-146a on NF-κB expression level in human umbilical vein endothelial cells under hyperglycemic condition. | Latest News

The role of miR-146a on NF-κB expression level in human umbilical vein endothelial cells under hyperglycemic condition

Concurrent with the creation of cellular hyperglycemia (25 mmol/L for 24 h), human umbilical vein endothelial cells (HUVECs ... and TRAF6 mRNA levels under hyperglycemic condition. These results demonstrate that the expression of miR-146a is upregulated ... read more

miR-146a regulates glucose induced upregulation of inflammatory cytokines extracellular matrix proteins in the retina and kidney in diabetes

Hyperglycemic damage to the endothelial cells (ECs ... following incubation with various levels of glucose with or without miR-146a mimic transfection. In the retina and kidneys of WT mice with diabetes, increased expression of inflammatory markers ... read more

Nrf2 Transcription Factor and Heme Oxygenase-1 as Modulators of Vascular Injury and Angiogenesis

Although the angiogenic involvement of HO-1 in physiological states and under conditions of tissue damage is well demonstrated, a direct role of Nrf2 in the ... angiogenic activities of human umbilical vein endothelial cells (HUVEC) by decreasing their ... read more

High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

Citation: Mortuza R, Chen S, Feng B, Sen S, Chakrabarti S (2013) High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in ... and grown in EC basal medium 2 (EBM-2, complete). Human umbilical vein ECs (HUVECs) were obtained ... read more

Epigenetic Mechanisms in the Pathogenesis of Diabetic Retinopathy

Recently, important roles of various epigenetic mechanisms ... has a close relation to DR. The retinas and retinal endothelial cells (RECs), from streptozotocin (STZ)-treated rats, kept in PC show increased expression of HDAC1, HDAC2 and HDAC8, and reduced ... read more

MicroRNAs in Hyperglycemia Induced Endothelial Cell Dysfunction

Under hyperglycemic conditions, the endothelial cells become dysfunctional. In this study, we investigated the miRNA expression changes in human umbilical vein endothelial ... in the pre-diabetic condition (IFG) indicates their possible role as potential ... read more

Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells.

Moreover, intra/extracellular miR-126-3p levels were measured in human endothelial cells (HUVECs) undergoing senescence under ... of the chronic hyperglycemic condition found in vivo in diabetic patients. Microarray analysis of miRs expression during ... read more

Inflammation, Atherosclerosis, and Coronary Artery Disease

Recent research has shown that inflammation plays a key role in coronary artery disease (CAD) and other manifestations of atherosclerosis. Immune cells dominate ... controlled at several levels: inflammatory cytokines induce the expression of MMP genes ... read more

The role of miR-146a on NF-κB expression level in human umbilical vein endothelial cells under hyperglycemic condition.

Concurrent with the creation of cellular hyperglycemia (25 mmol/L for 24 h), human umbilical vein endothelial cells (HUVECs ... and TRAF6 mRNA levels under hyperglycemic condition. These results demonstrate that the expression of miR-146a is upregulated ... read more
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